Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

Mesenteric lymph nodes infection with Linguatula serrata nymphs in cattle

871 mesenteric lymph nodes taken from 110 native cattle from Urmia slaughter-house with differentages were examined for Linguatula serrata infection. The lymph nodes were studied based on their colourand consistency. 44% of the cattle were found positive for L. serrata infection. The number of parasitesisolated from each infected lymph node varied from 1 to 69 with a mean of 5.48. There were no...

CD8+ T Lymphocyte Subsets in Bladder Tumor Draining Lymph Nodes

Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. Objective: To investigate the percentages of CD8+ lymphocytes and their subsets in...

Dendritic Cells to Pancreatic Lymph Nodes Diabetes through Tolerogenic Recruitment of Activated NKT Cells Inhibit Autoimmune

Trophoblast cells induce a tolerogenic profile in dendritic cells.

BACKGROUND Dendritic cells (DCs), which are biased toward a tolerogenic profile, play a pivotal role in tissue-remodeling processes and angiogenesis at the maternal-fetal interface. Here, we analyzed the effect of trophoblast cells on the functional profile of DCs to gain insight on the tolerogenic mechanisms underlying the human placental-maternal dialog at early stages of gestation. METHODS...

How tolerogenic dendritic cells induce regulatory T cells.

Since their discovery by Steinman and Cohn in 1973, dendritic cells (DCs) have become increasingly recognized for their crucial role as regulators of innate and adaptive immunity. DCs are exquisitely adept at acquiring, processing, and presenting antigens to T cells. They also adjust the context (and hence the outcome) of antigen presentation in response to a plethora of environmental inputs th...